Overview

According to the National Institutes of Health, over 40 million adults in the United States and over 1 billion people worldwide suffer from chronic pain each year, making it the most frequent cause for people to seek medical help. Chronic pain is a growing problem, not only in terms of the significant number of people impacted, but also due to the burden it places on our healthcare system. Chronic pain often results in abuse and addiction issues, which has led to a widespread and growing fatality rate.

At Centrexion Therapeutics, we believe that the most effective way to treat chronic pain is through therapies that specifically target the origin of the pain signal. This approach differs from other treatments such as opioids, which bind to specific receptors located throughout the body including in the brain, spinal cord and other nervous tissue rather than the specific source of chronic pain in the peripheral nervous system, or NSAIDs and steroids, which target the inflammatory response, not pain signaling.

¹“Chronic pain” defined as pain most days of the week for at least 3 months. “Prevalence and Profile of High-Impact Chronic Pain in the United States”. Pitcher, M.H. et al. 2011, J. Pain