Centrexion Therapeutics aims to address the need in pain treatment while also avoiding the significant challenges and side effects that come with currently available therapies.

Why Pain?

Chronic pain is a growing problemnot only in terms of the significant number of people that are impacted and the burden this places on our healthcare system, but also because of the abuse and addiction issues, as well as deaths, that have arisen from the high use of opioids to treat chronic pain.

One out of every 10 adults is diagnosed with chronic pain each year worldwide, making it the most common symptom driving people to seek medical help.

As our population ages, the number of people experiencing chronic pain is expected to grow, increasing the burden on our already taxed healthcare system and the possibility of people becoming addicted to their prescribed opioid treatments. Currently available non-opioid treatments, while avoiding the abuse and addiction issues associated with opioid treatments, offer limited pain relief but significant risks as well, such as gastrointestinal, cardiovascular, central nervous system, renal and other adverse effects, including organ failure and death.

We believe that our broad therapeutic pipeline of non-opioid chronic pain therapeutics is uniquely positioned to address the limitations of currently available therapies by providing safe, effective and long-term pain treatment solutions.

Sources: 1. Global Industry Analysts, Inc. (http://www.prweb.com/pdfdownload/8052240.pdf) 2. The American Academy of Pain Medicine (http://www.painmed.org/patientcenter/facts_on_pain.aspx) 3. Substance Abuse and Mental Health Services Administration (http://www.samhsa.gov/data/) 4. Wallace, J., et al, (2017). Knee osteoarthritis has doubled in prevalence since the mid-20th century (http://www.pnas.org/content/early/2017/08/08/1703856114). 5. UpToDate database, accessed August 2018. 6. 2Nahin, R.L. (2015) Estimates of Pain Prevalence and Severity in Adults: United States 2012, J. Pain 16(8): 769-780